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dc.contributor.authorPornthep Chanthavanichen_US
dc.contributor.authorChristine Luxemburgeren_US
dc.contributor.authorChukiat Sirivichayakulen_US
dc.contributor.authorKeswadee Lapphraen_US
dc.contributor.authorKrisana Pengsaaen_US
dc.contributor.authorSutee Yoksanen_US
dc.contributor.authorArunee Sabchareonen_US
dc.contributor.authorJean Langen_US
dc.contributor.otherSanofi Pasteur SAen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThe Institute of Science and Technology for Research and Development, Mahidol Universityen_US
dc.contributor.otherSanofi Pasteuren_US
dc.identifier.citationAmerican Journal of Tropical Medicine and Hygiene. Vol.75, No.1 (2006), 26-28en_US
dc.description.abstractFrom 1992 to 1997, 140 Thai children 4-15 years of age received an investigational live attenuated tetravalent dengue vaccine (LATDV). These children were contacted 3-8 years later in 2001 to assess humoral immunity and investigate whether they were subsequently at higher risk of developing severe dengue. One hundred thirteen were successfully contacted and participated in this retrospective cohort study with two age- and address-matched controls per vaccinee. The number of vaccinated subjects with neutralizing antibodies increased compared with 3-8 years earlier, which was probably due to subsequent wild-type dengue infections. There were no excess hospitalizations for clinically suspected dengue fever (DF) or dengue hemorrhagic fever (DHF) in vaccinees (one with DF and three with DHF) compared with controls (14 with DHF). Results suggest that preexisting dengue antibodies induced by LATDV do not enhance dengue illness, and the use of the vaccine in a dengue-endemic area is safe. Copyright © 2006 by The American Society of Tropical Medicine and Hygiene.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleImmune response and occurrence of dengue infection in Thai children three to eight years after vaccination with live attenuated tetravalent dengue vaccineen_US
Appears in Collections:Scopus 2006-2010

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