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dc.contributor.authorAmornrat Waitayakulen_US
dc.contributor.authorSangdao Somsrien_US
dc.contributor.authorJetsumon Sattabongkoten_US
dc.contributor.authorSornchai Looareesuwanen_US
dc.contributor.authorLiwang Cuien_US
dc.contributor.authorRachanee Udomsangpetchen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherArmed Forces Research Institute of Medical Sciences, Thailanden_US
dc.contributor.otherPennsylvania State Universityen_US
dc.identifier.citationActa Tropica. Vol.98, No.1 (2006), 66-73en_US
dc.description.abstractDuring blood feeding, arthropod vectors inject saliva into vertebrate hosts. The saliva is biochemically complex and pharmacologically active, and may play an important role in pathogen transmission. To examine whether mosquito saliva could elicit humoral immune response in humans under natural conditions, we have collected sera from malaria patients, healthy villagers, and people from a non-malarious region in Thailand. Here we have demonstrated that anti-Anopheles salivary protein antibodies occurred predominantly in patients with acute Plasmodium falciparum or P. vivax malaria, whereas people from a non-malarious area had no such antibodies. Besides, antibody levels against mosquito salivary proteins in malaria patients were highly variable, which may be related to the levels of mosquito exposure. Despite variability, patients' sera with high IgG titers consistently detected several proteins in Anopheles dirus salivary gland protein extracts. Immunohistochemical staining of Anopheles salivary glands with human sera showed that the salivary gland-specific IgGs reacted strongly with the median lobe. Comparison using Anopheles and Aedes salivary proteins suggests that the anti-salivary protein antibodies detected in malaria patients were Anopheles-specific, consistent with the major malaria vector status of An. dirus in this area. © 2006 Elsevier B.V. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleNatural human humoral response to salivary gland proteins of Anopheles mosquitoes in Thailanden_US
Appears in Collections:Scopus 2006-2010

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