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Title: T cell responses in dengue hemorrhagic fever: Are cross-reactive T cells suboptimal?
Authors: Juthathip Mongkolsapaya
Thaneeya Duangchinda
Wanwisa Dejnirattisai
Sirijit Vasanawathana
Panisadee Avirutnan
Aroonroong Jairungsri
Nuanpan Khemnu
Nattaya Tangthawornchaikul
Pojchong Chotiyarnwong
Kanokwan Sae-Jang
Michael Koch
Yvonne Jones
Andrew McMichael
Xiaoning Xu
Prida Malasit
Gavin Screaton
Hammersmith Hospital
Mahidol University
Khon Kaen Regional Hospital
Thailand National Center for Genetic Engineering and Biotechnology
Wellcome Trust
John Radcliffe Hospital
Keywords: Immunology and Microbiology
Issue Date: 15-Mar-2006
Citation: Journal of Immunology. Vol.176, No.6 (2006), 3821-3829
Abstract: Dengue virus infection poses a growing public health and economic burden in a number of tropical and subtropical countries. Dengue circulates as a number of quasispecies, which can be divided by serology into four groups or serotypes. An interesting feature of Dengue, recognized over five decades ago, is that most severe cases that show hemorrhagic fever are not suffering from a primary infection. Instead, they are reinfected with a virus of different serotype. This observation poses considerable problems in vaccine design, and it is therefore imperative to gain a full understanding of the mechanisms underlying this immunological enhancement of disease. In this study, we examined a T cell epitope restricted by HLA-A*24, a major MHC class I allele, in Southeast Asia in a cohort of children admitted to a hospital with acute Dengue infection. The cytokine profiles and the degranulation capacity of T cells generated to this epitope are defined and compared across different viral serotypes. Cross-reactive Dengue-specific T cells seem to show suboptimal degranulation but high cytokine production, which may contribute to the development of the vascular leak characteristic of Dengue hemorrhagic fever. Copyright © 2006 by The American Association of Immunologists, Inc.
ISSN: 00221767
Appears in Collections:Scopus 2006-2010

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