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Title: Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations
Authors: Paul N. Newton
Steven Ward
Brian J. Angus
Wirongrong Chierakul
Arjen Dondorp
Ronnatrai Ruangveerayuth
Kamolrat Silamut
Pramote Teerapong
Yupin Suputtamongkol
Sornchai Looareesuwan
Nicholas J. White
Mahidol University
Churchill Hospital
Liverpool School of Tropical Medicine
Mae Sot General Hospital
Faculty of Medicine, Siriraj Hospital, Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Feb-2006
Citation: Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.100, No.2 (2006), 184-186
Abstract: A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria. © 2005 Royal Society of Tropical Medicine Hygiene. Published by Elsevier Ltd. All rights reserved.
ISSN: 00359203
Appears in Collections:Scopus 2006-2010

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