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Title: Prospective evaluation of a rapid immunochromogenic cassette test for the diagnosis of melioidosis in northeast Thailand
Authors: Allen C. Cheng
Sharon J. Peacock
Direk Limmathurotsakul
Gumphol Wongsuvan
Wirongrong Chierakul
Premjit Amornchai
Nongluk Getchalarat
Wipada Chaowagul
Nicholas J. White
Nicholas P.J. Day
Vanaporn Wuthiekanun
Mahidol University
Menzies School of Health Research
Sappasitthiprasong Hospital
Nuffield Department of Clinical Medicine
Geelong Hospital
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2006
Citation: Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.100, No.1 (2006), 64-67
Abstract: A prospective study was performed to compare a rapid immunochromogenic cassette test (ICT) with the indirect haemagglutination assay (IHA) and clinical rules for the diagnosis of melioidosis in an endemic area. The sensitivity and specificity of the IgG ICT was 86% and 47%, and the IgM ICT was 82% and 47%, respectively. These were similar to the results for IHA (sensitivity 73%, specificity 64%) and clinical rules (73% and 37%). ICT lacks clinical utility as a result of high background rates of positive Burkholderia pseudomallei serology in this population. Low sensitivity and specificity of clinical rules is consistent with the protean manifestations of melioidosis and clinical difficulty in identifying patients with melioidosis. © 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
ISSN: 00359203
Appears in Collections:Scopus 2006-2010

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