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Title: Study on serum transcobalamin II in patients with murine typhus.
Authors: Cheeraratana Cheeramakara
Kriyaporn Songmeang
Wanyarat Nakosiri
Nopachai Suthisai
Apichart Nontprasert
Suvit Areekul
Mahidol University
Keywords: Medicine
Issue Date: 1-Dec-2006
Citation: The Southeast Asian journal of tropical medicine and public health. Vol.37 Suppl 3, (2006), 145-148
Abstract: We measured the serum transcobalamin II in murine typhus- infected patients (n = 16) admitted to the Hospital for Tropical Diseases in 1996-1997, compared with healthy controls (n = 60). The results showed that the transcobalamin II (TCII) and total serum unsaturated vitaminB12 binding capacity (UBBC) in patients with murine typhus (2,126.5 pg/ml, range 1,262-4,568 and 3,771.5 pg/ml, range 1,576-6,763 pg/ml) were statistically significantly higher than normal subjects (987.5 pg/ml, range 678-2,000 pg/ml and 1,402 pg/ml, range 932-2,470 ml) (p<0.001). Serum TCII levels in patients (63%) were elevated during the febrile period and returned to normal post-treatment. These findings suggest that patients with murine typhus had stimulation of reticulo-endothelial system, spleen, mesenteric lymph nodes, liver and skin and then released TCII into the blood circulation. The elevation in TCII may be used for confirming a diagnosis of murine typhus.
ISSN: 01251562
Appears in Collections:Scopus 2006-2010

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