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Title: Homocysteine, MTHFR C677 T, vitamin B12, and folate levels in Thai children with ischemic stroke: A case-control study
Authors: Nongnuch Sirachainan
Pornsri Tapanapruksakul
Anannit Visudtibhan
Ampaiwan Chuansumrit
Cheeraratana Cheeramakara
Kalayanee Atamasirikul
Sukanya Chotsuppakarn
Suvit Areekul
Mahidol University
Keywords: Medicine
Issue Date: 1-Dec-2006
Citation: Journal of Pediatric Hematology/Oncology. Vol.28, No.12 (2006), 803-808
Abstract: Hyperhomocysteinemia has been identified as a risk factor for venous and arterial thrombosis especially in adult populations. Twenty-eight patients with an initial diagnosis of ischemic stroke and 100 controls, aged ≤18 years, were enrolled in this study. The mean plasma total homocysteine (tHcy) levels in patients and controls were significantly different with values of 8.7±3.6 and 7.5±2.4 μmol/L, respectively (P=0.01). The plasma tHcy at the 95th percentile was 11.5 μmol/L and patients whose plasma tHcy was above the 95th percentile had an odds ratio of 8.2 (95% confidence interval 1.4-47.2, P=0.02) for developing ischemic stroke. The genetic and acquired factors that could have affected plasma tHcy levels were studied and no differences were found between patients and controls. Factors that were investigated were vitamin B12, red blood cell folate, and serum folate levels as well as methylenetetrahydrofolate reductase C677T polymorphism. It is of note, however, that subjects whose plasma tHcy was above the 95th percentile had significantly lower serum folate levels (P=0.02). © 2006 Lippincott Williams & Wilkins, Inc.
ISSN: 15363678
Appears in Collections:Scopus 2006-2010

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