Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: Dengue virus infections in the first 2 years of life and the kinetics of transplacentally transferred dengue neutralizing antibodies in Thai children
Authors: Krisana Pengsaa
Christine Luxemburger
Arunee Sabchareon
Kriengsak Limkittikul
Sutee Yoksan
Laurent Chambonneau
Udom Chaovarind
Chukiat Sirivichayakul
Keswadee Lapphra
Pornthep Chanthavanich
Jean Lang
Mahidol University
Rajavithi Hospital
Sanofi Pasteur SA
Keywords: Medicine
Issue Date: 1-Dec-2006
Citation: Journal of Infectious Diseases. Vol.194, No.11 (2006), 1570-1576
Abstract: Background. Understanding dengue virus infection in children and the kinetics of maternal dengue neutralizing antibodies is essential for effective dengue immunization of children in endemic areas. Methods. Serum samples from 219 mother-child pairs and 140 children at 3, 6, 9, 12, 18, and 24 months of age from Bangkok, Thailand, were tested for serotype-specific dengue antibodies. Febrile episodes in the children were recorded. Results. Antibodies were found in 97% of cord serum samples and disappeared in 27%, 80%, and 95% of the children by the age of 6, 9, and 12 months, respectively. Geometric mean titers (GMTs) of the antibodies to 4 dengue serotypes decreased to 5.4-15.5 in 6-month-old infants. Eleven of 12 children acquired dengue virus infection at 6 months of age and beyond; 1 had the infection at 3 months of age. Two exhibited undifferentiated febrile illnesses, and 10 had subclinical infections. Conclusions. Evidence of dengue virus infection and very low GMTs against all dengue serotypes in children at 6 months of age and beyond was demonstrated. There was no evidence that maternal antibodies were harmful to infants. Dengue virus infection rates increase from 12 months of age onward. These data provide information for supporting the optimal age at vaccination. © 2006 by the Infectious Diseases Society of America. All rights reserved.
ISSN: 00221899
Appears in Collections:Scopus 2006-2010

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.