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Title: Mycobacterium avium and Burkholderia pseudomallei (Melioidosis) coinfection in an HIV-positive patient
Authors: Wadchara Pumpradit
Koya Ariyoshi
Wimol Petkanchanapong
Nuanjun Wichukchinda
Angkana Chaiprasert
Archawin Rojanawat
Pathom Sawanpanyalert
Panita Pathipvanich
Thailand Ministry of Public Health
Lampang Hospital
Mahidol University
Keywords: Medicine
Issue Date: 1-Dec-2006
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.24, No.4 (2006), 239-243
Abstract: A 29 year old HIV positive Thai female with CD4 count of 10 cells/mm3 presented with chronic diffuse abdominal pain, fever, weight loss, anemia and leucopenia. Ultrasonography demonstrated diffuse upper abdominal lymphadenopathy with ascites. Microbiological and molecular work up of the specimen obtained by ultrasound-guided lymph node aspiration revealed co-infection with Burkholderia pseudomallei and Mycobacterium avium. Indirect hemagglutination, IgM-indirect fluorescent antibody, and IgG-indirect fluorescent antibody to Burkholderia pseudomallei were < 1:20, < 1:50 and < 1:50, respectively, at nine months, four months before the culture diagnosis and two months, eight months after the culture diagnosis of Burkholderia pseudomallei infection. The patient was treated initially with two weeks of intravenous ceftazidime, followed by oral cotrimoxazole, doxycycline and chloramphenicol. Clarithromycin and ofloxacin were added after the identification of Mycobacterium avium and its susceptibility test. The patients demonstrated clinical improvement with decreasing abdominal pain and resolution of fever.
ISSN: 0125877X
Appears in Collections:Scopus 2006-2010

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