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Title: Use of Hachinski Ischemic Score in the Memory Clinic: Thai experience
Authors: Sasitorn Siritho
Vorapun Senanarong
Arpas Nako
Wattananchai Chotinaiwattarakul
Piyanuj Jamjumrus
Suthipol Udompunthuruk
Niphon Poungvarin
Mahidol University
Keywords: Medicine
Issue Date: 1-Nov-2006
Citation: Journal of the Medical Association of Thailand. Vol.89, No.11 (2006), 1822-1828
Abstract: Background: The validity of Hachinski Ischemic Score (HIS) in differentiating between Alzheimer's disease (AD) and Vascular dementia(VaD) has been questioned and compared with the gold standard autopsy. Objective: To confirm that the HIS can be used to differentiate related VaD from AD in a Thai population. Material and Method: A prospective study of 398 patients who were attending the Memory Clinic, at Siriraj Hospital between January 2001 and October 2003. Results: The 214 patients, with a mean age of 71.15 ± 10.20 years, were classified as AD, VaD or mixed dementia (AD with cerebrovascular disease) in proportion of 60.2%, 30.4%, and 9.3% respectively. The authors propose HIS at 5 as a cut off point to differentiate patients with AD and those with VaD or AD with cerebrovascular disease with sensitivity of 85.3% and specificity of 72.9%. Conclusion: The HIS can be applied to differentiate dementia related vascular etiology from AD in a Thai population.
ISSN: 01252208
Appears in Collections:Scopus 2006-2010

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