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Title: Association between HLA class II alleles and autoimmune hepatitis type 1 in Thai patients
Authors: Tawesak Tanwandee
Sutep Wanichapol
Sasijit Vejbaesya
Sivaporn Chainuvati
Watcharasak Chotiyaputta
Faculty of Medicine, Thammasat University
Siriraj Hospital
Mahidol University
Keywords: Medicine
Issue Date: 1-Nov-2006
Citation: Journal of the Medical Association of Thailand. Vol.89, No.SUPPL. 5 (2006)
Abstract: Objective: To investigate the association between HLA class II alleles and autoimmune hepatitis (AIH) type I in Thai patients. Material and Method: The clinical data of 50 autoimmune hepatitis patients type 1 (AIH) at Siriraj hepatitis clinic were analysed, 37 of whom were tested for HLA class II genotyping using polymerase chain reaction and sequence-specific oligonucleotide technique (PCR-SSO). Results: AIH is an uncommon chronic hepatitis in Thailand with females predominant. The HLA DRB1*0301, and DQA1*0101 were significantly associated with AIH patients when compared to controls; (OR = 3.92 [1.18-13.30], p 0.021, OR = 2.31 [1.13-4.73], p 0.019, respectively). When 18 patients with "definite" AIH were analysed, only HLA DRB1*0301 was still significantly associated with AIH (OR = 5.22, 95%CI = 1.28-20.92, p 0.015) Conclusion: HLA genotyping has shown that HLA DRB1*0301 and HLA DQA1*0101 were significantly associated with AIH.
ISSN: 01252208
Appears in Collections:Scopus 2006-2010

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