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Title: Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study
Authors: Tisha Prabriputaloong
Todd P. Margolis
Thomas M. Lietman
Ira G. Wong
Rookaya Mather
David C. Gritz
University of California, San Francisco
Mahidol University
Stanford University
Western University
Permanente Medical Group
Keywords: Medicine
Issue Date: 1-Nov-2006
Citation: American Journal of Ophthalmology. Vol.142, No.5 (2006)
Abstract: Purpose: To determine whether atopy is associated with herpes simplex virus (HSV) ocular disease. Design: Retrospective, population-based, case-control study. Methods: setting: Large, regional health maintenance organization (Northern California Kaiser Permanente). study Population: 1,042,351 people over a one-year period. observation Procedures: Electronic database search for HSV ocular disease and subsequent chart review determined study eligibility. Two age-matched control groups (one population-based and one clinic-based) were randomly chosen. Medical record review determined the presence of atopy. Severe atopic disease was defined by diagnostic code or illness requiring an emergency room visit, hospitalization, or treatment with a systemic corticosteroid. main Outcome Measures: Presence of HSV eye disease, presence of atopy, and characterization of atopy severity. Results: HSV eye disease was found in 172 patients. HSV cases had a greater prevalence of atopy (34%, 58/172) than the clinic-based (25%, 43/172) or the population-based controls (21%, 36/172, odds ratio (OR) 1.5, 95% confidence interval (CI) 0.9 to 2.6 and OR 1.9, 95%, CI 1.1 to 3.3, respectively). The association of HSV ocular disease with severe atopy was even greater, with a history of severe atopic disease in 13% (22/172) of patients with HSV ocular disease as compared with 6% (11/172) of patients in the clinic control group and 3% (5/172) of patients in the population control group (OR 2.0, 95% CI 0.7 to 5.9 and OR 4.8, 95% CI 1.6 to 19.2, respectively). Conclusions: Patients with HSV ocular disease are more likely to have a history of atopic disease, especially severe atopic disease, than age-matched controls. © 2006 Elsevier Inc. All rights reserved.
ISSN: 00029394
Appears in Collections:Scopus 2006-2010

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