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Title: Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women
Authors: Kathryn Chu
Sukhum Jiamton
Jacques Pepin
Frances Cowan
Bussakorn Mahakkanukrauh
Ruengpung Suttent
Noah J. Robinson
Sylvie Deslandes
Eric Frost
Pongsakdi Chaisilwattana
Puan Suthipinittharm
Heiner Grosskurth
David Brown
Shabbar Jaffar
London School of Hygiene & Tropical Medicine
Mahidol University
Universite de Sherbrooke
GlaxoSmithKline plc.
Medical Research Council Programme on AIDS in Uganda
Health Protection Agency
Keywords: Medicine
Issue Date: 30-Oct-2006
Citation: International Journal of STD and AIDS. Vol.17, No.10 (2006), 681-686
Abstract: We studied the association between herpes simplex virus type-2 (HSV-2) and HIV-1 viralload in plasma, semen, cervico-vaginal secretions and genital ulcers. Forty-seven (68%) men and 57 (80%) women were HSV-2 antibody positive, of whom 12 (26%, 95% confidence interval [CI] 20, 32) and five (8%, 95% CI 4, 12), respectively, had HSV-2 genital shedding detected by polymerase chain reaction. The mean HIV-1 seminal and cervico-vaginal viral loads did not differ significantly according to the presence of HSV-2 shedding. Eleven men and 15 women presented with genital ulcers; all ulcers were due to HSV-2. Ten men and nine women were followed up over six days: the mean (95% CI) HIV-1 log viral load copies/mL in the genital ulcers at baseline and final visits were 2.5 (2.3, 2.7) and 3.1 (2.0, 4.2) for men and 3.0 (2.6, 3.4) and 2.7 (2.3, 3.1) for women. These findings do not support the hypothesis that HSV-2 increases the HIV-1 viral load in genital secretions.
ISSN: 09564624
Appears in Collections:Scopus 2006-2010

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