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dc.contributor.authorKathryn Chuen_US
dc.contributor.authorSukhum Jiamtonen_US
dc.contributor.authorJacques Pepinen_US
dc.contributor.authorFrances Cowanen_US
dc.contributor.authorBussakorn Mahakkanukrauhen_US
dc.contributor.authorRuengpung Suttenten_US
dc.contributor.authorNoah J. Robinsonen_US
dc.contributor.authorSylvie Deslandesen_US
dc.contributor.authorEric Frosten_US
dc.contributor.authorPongsakdi Chaisilwattanaen_US
dc.contributor.authorPuan Suthipinittharmen_US
dc.contributor.authorHeiner Grosskurthen_US
dc.contributor.authorDavid Brownen_US
dc.contributor.authorShabbar Jaffaren_US
dc.contributor.otherLondon School of Hygiene & Tropical Medicineen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversite de Sherbrookeen_US
dc.contributor.otherGlaxoSmithKline plc.en_US
dc.contributor.otherMedical Research Council Programme on AIDS in Ugandaen_US
dc.contributor.otherHealth Protection Agencyen_US
dc.identifier.citationInternational Journal of STD and AIDS. Vol.17, No.10 (2006), 681-686en_US
dc.description.abstractWe studied the association between herpes simplex virus type-2 (HSV-2) and HIV-1 viralload in plasma, semen, cervico-vaginal secretions and genital ulcers. Forty-seven (68%) men and 57 (80%) women were HSV-2 antibody positive, of whom 12 (26%, 95% confidence interval [CI] 20, 32) and five (8%, 95% CI 4, 12), respectively, had HSV-2 genital shedding detected by polymerase chain reaction. The mean HIV-1 seminal and cervico-vaginal viral loads did not differ significantly according to the presence of HSV-2 shedding. Eleven men and 15 women presented with genital ulcers; all ulcers were due to HSV-2. Ten men and nine women were followed up over six days: the mean (95% CI) HIV-1 log viral load copies/mL in the genital ulcers at baseline and final visits were 2.5 (2.3, 2.7) and 3.1 (2.0, 4.2) for men and 3.0 (2.6, 3.4) and 2.7 (2.3, 3.1) for women. These findings do not support the hypothesis that HSV-2 increases the HIV-1 viral load in genital secretions.en_US
dc.rightsMahidol Universityen_US
dc.titleAssociation between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and womenen_US
Appears in Collections:Scopus 2006-2010

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