Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/23593
Title: Candida guilliermondii, an opportunistic fungal pathogen with decreased susceptibility to fluconazole: Geographic and temporal trends from the ARTEMIS DISK antifungal surveillance program
Authors: M. A. Pfaller
D. J. Diekema
M. Mendez
C. Kibbler
P. Erzsebet
S. C. Chang
D. L. Gibbs
V. A. Newell
Jorge Finquelievich
Nora Tiraboschi
David Ellis
Dominique Frameree
Annemarie van den Abeele
Jean Marc Senterre
Arnaldo Colombo
Robert Rennie
Steve Sanche
Bijie Hu
Yingchun Xu
Yingyuan Zhang
Nan Shan Zhong
Pilar Rivas
Angela Restrepo
Catalina Bedout
Ricardo Vega
Matilde Mendez
Nada Mallatova
Stanislava Dobiasova
Julio Ayabaca
Jeannete Zurita
M. Mallie
E. Candolfi
W. Fegeler
A. Haase
G. Rodloff
W. Bar
V. Czaika
George Petrikos
Erzsébet Puskás
Ilona Doczi
Mestyan Gyula
Radka Nikolova
Uma Banerjee
Nathan Keller
Vivian Tullio
Gian Carlo Schito
Giacomo Fortina
Gian Piero Testore
Domenico D'Antonio
Giorgio Scalise
Pietro Martino
Graziana Manno
Kee Peng
Celia Alpuche
Jose Santos
Eduardo Rodriguez Noriega
Mussaret Zaidi
Jacques F.G.M. Meis
Egil Lingaas
Danuta Dzierzanowska
Waclaw Pawliszyn
Mariada Luz Martins
Luis Albuquerque
Laura Rosado
Rosa Velho
Jose Amorim
Vera N. Ilina
Olga I. Kretchikova
Galina A. Klyasova
Sophia M. Rozanova
Irina G. Multykh
Nikolay N. Klimko
Elena D. Agapova
Natalya V. Dmitrieva
Abdul Mohsen Al-Rasheed
Jan Trupl
Leon Langsadl
Alena Vaculikova
Hupkova Helena
Denise Roditi
Anwar Hoosen
H. H. Crewe-Brown
M. N. Janse van Rensburg
Adriano Duse
Kyungwon Lee
Mi Na Kim
A. del Palacio
Aurora Sanchez-Sousa
Jacques Bille
K. Muhlethaler
Jen Hsien Wang
Malai Vorachit
Deniz Gur
Volkan Korten
John Paul
Brian Jones
F. Kate Gould
Chris Kibbler
Nigel Weightman
Ian M. Gould
University of Iowa Carver College of Medicine
Hospital Militar Central, Bogota
UCL
ANTSZ BAZ Megyei Intezete
National Taiwan University Hospital
Giles Scientific, Inc.
Universidad de Buenos Aires
Hospital Escuela Gral.
Women's and Children's Hospital Adelaide
CHU de Jumet
St. Lucas Campus Heilige Familie
Centre Hospitalier Regional de La Citadelle
Universidade Federal de Sao Paulo
University of Alberta Hospital
Royal University Hospital
Zhongshan Hospital Shanghai
Peking Union Medical College
Huashan Hospital
Guangzhou Institute of Repiratory Disease
Universidad Nacional de Colombia
CIB
Hospital Ceske Budejovice
Hospital FF. AA HG1
Hospital Vozandes
Institut de Parasitologie
Westfalische Wilhelms-Universitat Munster
Rheinisch-Westfalische Technische Hochschule Aachen
Inst. F. Med. Mikrobiologie
Carl-Thiem-Klinikum
Humaine Kliniken
Laikon General Hospital
BAZ County Institute
Szegedi Tudomanyegyetem (SZTE)
Pecsi Tudomanyegyetem
Szent Laszlo Hospital
All India Institute of Medical Sciences, New Delhi
Chaim Sheba Medical Center Israel
Universita degli Studi di Torino
Universita degli Studi di Genova
Ospedale di Novara
Universita degli Studi di Roma Tor Vergata
Ospedale Civile di Pescara
Instituto di Malattie Infettive
University of Malaya
Hospital General de Mexico
Universidad de Guadalajara
Hospital General O'Horan
Nijmegen Interdenominational Hospital Canisius-Wilhelmina
Rikshospitalet-Radiumhospitalet HF
Instytut Pomnik-Centrum Zdrowia Dziecka
Pracownia Bakteriologii
Universidade Nova de Lisboa, Instituto de Higiene e Medicina Tropical
Centro Hospitalar e Universitario de Coimbra
National Research Center for Hematology
Hospital Geral de Santo Antonio
North-Western State Medical University named after I.I. Mechnikov
Institute of Antimicrobial Chemotherapy
City Clinical Hospital No.
Territory Center of Lab Diagnostics
Medical Mycology Research Institute
Irkutsk Regional Childrens Hospital
Oncology Research Center
Riyadh Military Hospital
National Cancer Center
NUTaRCH
Derer's University Hospital Slovakia
St. Cyril and Method's Hospital
Groote Schuur Hospital
Ga-Rankuwa Hospital
Baragwanath Hospital
University of the Free State
Johannesburg Hospital
Yonsei University College of Medicine
Asan Medical Center
Hospital 12 De Octobre
Hospital Ramon y Cajal
Centre Hospitalier Universitaire Vaudois
Universitat Bern
China Medical University Hospital Taichung
Mahidol University
Hacettepe Children's Hospital
Marmara Universitesi Tip Fakultesi
Royal Sussex County Hospital
Glasgow Royal Infirmary
Freeman Hospital
Friarage Hospital
Aberdeen Royal Infirmary
Leeds General Infirmary
Cardiff University
Wayne State University
The Mount Sinai Medical Center
Weill Cornell Medical Center
Stanford University Medical Center
University Hospitals Case Medical Center
University of Texas System
University of Virginia
Christiana Care
Gen del Este Dr. Domingo Luciani
Universitario de Caracas
Keywords: Medicine
Issue Date: 1-Oct-2006
Citation: Journal of Clinical Microbiology. Vol.44, No.10 (2006), 3551-3556
Abstract: Although a rare cause of invasive candidiasis, Candida guilliermondii has been reported to exhibit decreased susceptibility to antifungal agents. Aside from case reports and small surveys, there is little information regarding the epidemiology and antifungal susceptibility profile of C. guilliermondii. We report geographic and temporal trends in the isolation and antifungal susceptibilities of 1,029 C. guilliermondii clinical isolates collected from 127 medical centers as part of the ARTEMIS DISK Antifungal Surveillance Program. In addition, we report the in vitro susceptibility of 132 bloodstream isolates of C. guilliermondii to caspofungin. C. guilliermondii represented 1.4% of the 75,761 isolates collected from 2001 to 2003 and was most common among isolates from Latin America (3.7% versus 0.6 to 1.1%). Decreased susceptibility to fluconazole was noted (75% susceptible; range, 68 to 77% across regions), and voriconazole was more active in vitro against C. guilliermondii than fluconazole (91% susceptible; range, 88 to 93% across regions). Fluconazole was least active against isolates from dermatology (58%) and surgical (69%) services and against isolates associated with skin and soft tissue infection (68%, compared to 85% susceptible for bloodstream isolates). There was no evidence of increasing azole resistance over time among C. guilliermondii isolates tested from 2001 to 2003. Of 132 bloodstream isolates of C. guilliermondii tested against caspofungin, most were inhibited by ≤2 μg/ml (96%; MIC50/MIC90, 0.5/1.0 μg/ml). C. guilliermondii, a species that exhibits reduced susceptibility to fluconazole, is the sixth most frequently isolated Candida species from this large survey and may be an emerging pathogen in Latin America. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33947506669&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/23593
ISSN: 00951137
Appears in Collections:Scopus 2006-2010

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