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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/23696
Title: Circulating hTERT mRNA as a tumor marker in cholangiocarcinoma patients
Authors: Kawin Leelawat
Surang Leelawat
Thawee Ratanachu-Ek
Somboon Trubwongchareon
Jerasak Wannaprasert
Saad Tripongkaruna
Suchart Chantawibul
Panadda Tepaksorn
Rajavithi Hospital
Mahidol University
Rangsit University
National Institutes of Health, Bethesda
Keywords: Medicine
Issue Date: 14-Jul-2006
Citation: World Journal of Gastroenterology. Vol.12, No.26 (2006), 4195-4198
Abstract: Aim: To investigate human telomerase reverse transcriptase (hTERT) mRNA in the serum of cholangiocarcinoma patients. Methods: The serum of thirty three cholangiocarcinoma patients, forty one benign biliary tract disease patients and ten healthy volunteers were collected and analyzed for the expression of hTERT mRNA by real-time reverse transcriptase-polymerase chain reaction (RT-PCR). We then examined the correlation between values of serum hTERT mRNA and the pathological staging of cholangiocarcinoma. Results: hTERT mRNA was detected in 28 of 33 (84.85%) of serum obtained from cholangiocarcinoma patients and 9 of 41 (21.9%) of serum obtained from benign biliary tract disease patients. hTERT mRNA was not detected in any serum obtained from healthy volunteers. on the other hand the common tumor marker, CA19-9 was detected in 20 of 33 (60.6%) of serum obtained from cholangiocarcinoma patients and 8 of 41 (19.5%) of serum obtained from benign biliary tract disease patients. However, no correlation was found between the present of serum hTERT mRNA and tumor staging. Conclusion: These results indicate that the detection of circulating hTERT mRNA was identified in almost all cholangiocarcinoma patients. It offers a novel tumor marker, which can be used as a complementary study for diagnosis of cholangiocarcinoma. © 2006 The WJG Press. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33748605027&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/23696
ISSN: 10079327
Appears in Collections:Scopus 2006-2010

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