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Title: Plasmepsin II inhibitory activity of alkoxylated and hydroxylated chalcones
Authors: Nongluk Sriwilaijaroen
Mei Liu
Mei Lin Go
Prapon Wilairat
Mahidol University
University of
Keywords: Medicine
Issue Date: 1-Jul-2006
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.37, No.4 (2006), 607-612
Abstract: Sixteen antimalarial alkoxylated and hydroxylated chalcones were tested for their ability to inhibit recombinant plasmepsin II in vitro. The best inhibitory compounds had either a chloro or dimethylamino group at the 4-position of phenyl ring A in the chalcone template. Combination of the chalcones with chloroquine showed additivity or mild antagonism of Plasmodium falciparum K1 growth in culture.
ISSN: 01251562
Appears in Collections:Scopus 2006-2010

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