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Title: Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon
Authors: Swati B. Gupta
Christopher T. Mast
Nathan D. Wolfe
Vlad Novitsky
Sheri A. Dubey
Esper G. Kallas
Mauro Schechter
Bernard Mbewe
Eftyhia Vardas
Punee Pitisuttithum
Donald Burke
Dan Freed
Robin Mogg
Paul M. Coplan
Jon H. Condra
Romnie S. Long
Kiersten Anderson
Danilo R. Casimiro
John W. Shiver
Walter L. Straus
Merck & Co., Inc.
Johns Hopkins Bloomberg School of Public Health
Harvard School of Public Health
Universidade Federal de Sao Paulo
Universidade Federal do Rio de Janeiro
Malawi College of Medicine
Ministry of Population and Health
University of Witwatersrand
Mahidol University
Intl. Partnership for Microbicides
Merck Research Laboratories
Keywords: Medicine
Issue Date: 1-Jun-2006
Citation: Journal of Acquired Immune Deficiency Syndromes. Vol.42, No.2 (2006), 135-139
Abstract: An effective HIV type 1 (HIV-1) vaccine will likely require elicitation of broadly reactive cell-mediated immune (CMI) responses against divergent HIV-1 clades. We compared anti-HIV-1 T-cell immune responses among 363 unvaccinated adults infected with diverse HIV-1 clades. Response rates to clade B Gag and/or clade B Nef in Botswana (95%) and Cameroon (98%) were similar when compared with those in countries previously studied, including Brazil (92%), Thailand (96%), South Africa (96%), Malawi (100%), and the United States (100%). Substantial cross-clade cell-mediated immune responses in Botswana and Cameroon confirm previous findings in a larger, more genetically diverse collection of HIV-1 samples. Copyright © 2006 by Lippincott Williams & Wilkins.
ISSN: 15254135
Appears in Collections:Scopus 2006-2010

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