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Title: HLA-class II (DRB & DQB1) in Thai sudden unexplained death syndrome (Thai SUDS) families (Lai-Tai families)
Authors: Pensiri Himmunngan
Somkiat Sangwatanaroj
Songsak Petmitr
Duangkamol Viroonudomphol
Pakorn Siriyong
Pimpicha Patmasiriwat
Institute of Pathology
Faculty of Medicine, Chulalongkorn University
Mahidol University
Thailand Ministry of Public Health
Keywords: Medicine
Issue Date: 1-Mar-2006
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.37, No.2 (2006), 357-365
Abstract: Thai Sudden Unexplained Death Syndrome (Thai SUDS), or Lai-Tai, is a major health problem among rural residents of northeastern Thailand. The cause has been identified as a genetic disease. SUDS, a disorder found in Southeast Asia, is characterized by an abnormal electrocardiogram with ST-segment elevation in leads V1-V3, identical to that seen in Brugada Syndrome (Brugada Sign, BS) and sudden death due to ventricular fibrillation and cardiac arrest (represents an arrhythmogenic marker that identifies high-risk for SUDS). SUDS victims have a sleeping disorder (narcolepsy). The HLA-DR locus is tightly associated with narcoleptic Japanese patients and HLA-DR2, DQ haplotypes were also found in Oriental narcoleptic patients. These circumstances prompted us to study the association between the disease and HLA Class II by HLA DNA typing using a PCR-SSO method, with five Thai SUDS families (18 BS-positive subjects as the cases, and 27 BS-negatives as the controls). We found that the HLA-DRB1*12021 allele was significantly increased in BS-positive subjects (p=0.02; OR=4.5), the same as the HLA-DRB1* 12021-DQB1*0301/09 haplotype (p=0.01; OR=7.95). Our data suggests that the HLA-DRB1* 12021 allele associated with BS and the HLA-DRB1*12021-DQB1*0301/09 is a haplotype susceptible to arrhythmogenic markers that can identify a high risk for SUDS.
ISSN: 01251562
Appears in Collections:Scopus 2006-2010

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