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dc.contributor.authorWorawan Chumpiaen_US
dc.contributor.authorChayanon Peerapittayamongkolen_US
dc.contributor.authorPantep Angchaisuksirien_US
dc.contributor.authorNantarat Komanasinen_US
dc.contributor.authorKoichiro Mutaen_US
dc.contributor.authorKunnika Kuahaen_US
dc.contributor.authorHiroko Iidaen_US
dc.contributor.authorSumiko Inoueen_US
dc.contributor.authorYui Wadaen_US
dc.contributor.authorMasako Kuriharaen_US
dc.contributor.authorNaotaka Hamasakien_US
dc.contributor.authorSuthat Fucharoenen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherKyushu Universityen_US
dc.contributor.otherThe Institute of Science and Technology for Research and Development, Mahidol Universityen_US
dc.contributor.otherFaculty of Medicine, Siriraj Hospital, Mahidol Universityen_US
dc.contributor.otherFaculty of Medicine, Ramathibodi Hospital, Mahidol Universityen_US
dc.contributor.otherKhon Kaen Universityen_US
dc.contributor.otherGraduate School of Medical Sciencesen_US
dc.identifier.citationBlood Coagulation and Fibrinolysis. Vol.17, No.1 (2006), 13-18en_US
dc.description.abstractProtein C (PC) and protein S (PS) play key roles in an anticoagulant pathway in order to control the haemostatic system. We identified single nucleotide polymorphisms (SNPs) and/or haplotypes in the promoter and exons of the whole PC and PS genes and in the 3′-untranslated region of the PS gene in 55 Thai individuals. The PC gene revealed 10 haplotypes. One synonymous SNP at 2196 was found in the normal Thai population with a minor allele frequency of 4.90%. One homozygous mutation in exon 7, R147W, co-segregated with the synonymous SNP 2196 (homozygote) of the PC gene, resulting in decreased PC activity and antigenic levels. The PS gene revealed three haplotypes with two frequent dimorphisms in exon 15 and the 3′-untranslated region. The most frequent haplotype in the PS gene was H3(wild type). There was no correlation between the haplotypes of PC and PS genes with functional and antigenic levels of PC and PS. © 2006 Lippincott Williams & Wilkins.en_US
dc.rightsMahidol Universityen_US
dc.titleSingle nucleotide polymorphisms and haplotypes of protein C and protein S genes in the Thai populationen_US
Appears in Collections:Scopus 2006-2010

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