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Title: International collaborative survey on epidemiology of hepatitis E virus in 11 countries
Authors: Kenji Abe
Tian Cheng Li
Xin Ding
Khin Maung Win
Pradeep Krishna Shrestha
Vo Xuan Quang
Trinh Thi Ngoc
Teresa Casanovas Taltavull
Andrei V. Smirnov
Vasily F. Uchaikin
Pairoj Luengrojanakul
Hongxi Gu
Abdel Rahman El-Zayadi
Alfred M. Prince
Kaoru Kikuchi
Naohiko Masaki
Ayano Inui
Tetsutaro Sata
Naokazu Takeda
National Institute of Infectious Diseases
Yangon General Hospital
Tribhuvan University Teaching Hospital
Cho Ray Hospital
Bach Mai Hospital
Hospital Universitari de Bellvitge
Pirogov Russian National Research Medical University (RNRMU)
Mahidol University
Harbin Medical University
Cairo Liver Center
New York Blood Center
Okinawa Chubu Hospital
National Center for Global Health and Medicine
International University of Health and Welfare
Keywords: Medicine
Issue Date: 1-Jan-2006
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.37, No.1 (2006), 90-95
Abstract: We conducted seroepidemiological studies on antibody prevalence to hepatitis E virus (HEV) in 5,233 sera from 11 countries to ascertain the present state of HEV infection on a global basis. The prevalence of anti-HEV IgG increased with age in these tested countries, but the rate of antibody positivity was over 20% in the 16-30 year-old group in most of the participating countries, except for Japan, the USA, and Spain. Of patients with acute hepatitis of unknown etiology from Nepal, 56% (14/25) were positive for the IgM class of anti-HEV antibody. In addition, HEV RNAs in the serum from 3 Nepali patients who had the IgM antibody were detected by nested PCR and all of the HEV genes isolated belonged to genotype 1. Our results indicate that HEV is spreading worldwide, not only in developing countries, but also in more industrialized countries than previously thought.
ISSN: 01251562
Appears in Collections:Scopus 2006-2010

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