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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/23883
Title: NF-κB-associated MnSOD induction protects against β-amyloid-induced neuronal apoptosis
Authors: Pradoldej Sompol
Yong Xu
Wanida Ittarat
Chotiros Daosukho
Daret St. Clair
University of Kentucky College of Medicine
Mahidol University
Keywords: Neuroscience
Issue Date: 1-Jul-2006
Citation: Journal of Molecular Neuroscience. Vol.29, No.3 (2006), 279-288
Abstract: Expression of manganese superoxide dismutase (MnSOD), a nuclear-encoded mitochondrial primary antioxidant enzyme, is protective against various paradigms of oxidative stress-induced brain injury. We have shown previously that the presence of an intronic nuclear factor site, κB (NF-κB), in the MnSOD gene is essential for the induction of MnSOD by tumor necrosis factor α (TNF-α). However, whether activation of NF-κB is protective against oxidative stress-induced neuronal injury is unclear. In the present study, we demonstrate that TNF-α activates NF-κB activity in neuronal, SH-SY5Y, cells and preferentially enhances the binding of p50 and p65 to the promoter/enhancer regions of the MnSOD gene. Binding of NF-κB members to the MnSOD gene leads to the induction of MnSOD mRNA and protein levels. Consequently, induction of MnSOD by TNF-α primes neuronal cells to develop resistance against subsequent exposure to β-amyloid and FeSO4. Taken together, these results suggest that NF-κB might exert its protective function by induction of MnSOD leading to subsequent protection against oxidative stress-induced neuronal injury. Copyright © 2006 Humana Press Inc.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33750589672&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/23883
ISSN: 08958696
Appears in Collections:Scopus 2006-2010

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