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Title: Cytotoxic mycoepoxydiene derivatives from an endophytic fungus Phomopsis sp. isolated from Hydnocarpus anthelminthicus
Authors: Surasak Prachya
Suthep Wiyakrutta
Nongluksna Sriubolmas
Nattaya Ngamrojanavanich
Chulabhorn Mahidol
Somsak Ruchirawat
Prasat Kittakoop
Chulabhorn Research Institute
Chulalongkorn University
Mahidol University
The Institute of Science and Technology for Research and Development, Mahidol University
Keywords: Agricultural and Biological Sciences;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Oct-2007
Citation: Planta Medica. Vol.73, No.13 (2007), 1418-1420
Abstract: Mycoepoxydiene (1) and derivatives, deacetylmycoepoxydiene (2) and 2,3-dihydromycoepoxydiene (3), were isolated from a broth extract of the endophytic fungus, Phomopsis sp., which was isolated from a Thai medicinal plant, Hydnocarpus anthelminthicus. Compounds 1 and 2 exhibited potent cytotoxic activity, while a dihydro derivative 3 was inactive. The present work suggests that the α,β-unsaturated lactone moiety in mycoepoxydienes might be responsible for the cytotoxicity. © Georg Thieme Verlag KG Stuttgart.
ISSN: 00320943
Appears in Collections:Scopus 2006-2010

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