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Title: Elevated F<inf>2</inf>-isoprostanes in thalassemic patients
Authors: Chutima Matayatsuk
Chung Yung J. Lee
Ruchaneekorn W. Kalpravidh
Pornpan Sirankapracha
Prapin Wilairat
Suthat Fucharoen
Barry Halliwell
Mahidol University
Yong Loo Lin School of Medicine
The Institute of Science and Technology for Research and Development, Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 15-Dec-2007
Citation: Free Radical Biology and Medicine. Vol.43, No.12 (2007), 1649-1655
Abstract: This study was aimed at investigating oxidative stress in thalassemic patients by measurement of the oxidative damage biomarker, F2-isoprostanes (F2-IsoPs), using gas chromatography-mass spectrometry. The results showed that the mean value of urinary F2-IsoPs, normalized with creatinine, in the thalassemic group was significantly higher than that from healthy subjects (3.38 ± 2.15 ng/mg creatinine vs 0.86 ± 0.55 ng/mg creatinine, respectively), and the mean value of plasma total F2-IsoPs in the thalassemic group was also significantly higher than that from healthy subjects (0.39 ± 0.15 ng/ml vs 0.18 ± 0.03 ng/ml, respectively). Serum ferritin, erythrocyte superoxide dismutase (SOD), glutathione peroxidase, glutathione, and TBARS levels after treatment of erythrocytes with H2O2were also investigated, and serum ferritin and erythrocyte SOD levels were significantly higher in thalassemic patients. Our findings are consistent with oxidative stress in thalassemia patients. © 2007 Elsevier Inc. All rights reserved.
ISSN: 08915849
Appears in Collections:Scopus 2006-2010

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