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Title: Body fluid proteomics for biomarker discovery: Lessons from the past hold the key to success in the future
Authors: David M. Good
Visith Thongboonkerd
Jan Novak
Jean Loup Bascands
Joost P. Schanstra
Joshua J. Coon
Anna Dominiczak
Harald Mischak
University of Wisconsin Madison
Mahidol University
University of Alabama at Birmingham
Universite Paul Sabatier Toulouse III
University of Glasgow
Mosaiques Diagnostics and Therapeutics AG
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 1-Dec-2007
Citation: Journal of Proteome Research. Vol.6, No.12 (2007), 4549-4555
Abstract: Sparked by the article from Lescuyer and colleagues in a recent issue, we aim here to further encourage interest in and discussion of clinically relevant biomarker research. We express our view on proteomics for biomarker discovery by addressing multiple relevant issues, including the inherent differences between biological fluids (and how these differences affect current analytical approaches) and experimental design to maximize the efficiency of moving from the bench to the bedside. Herein, we also include suggestions for definition of the term "biomarker", based on the use of a set of universal characterization/validation requirements, and illustrate several recent examples of successful transitions of benchtop proteomic studies work to clinical practice. © 2007 American Chemical Society.
ISSN: 15353893
Appears in Collections:Scopus 2006-2010

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