Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: FTO polymorphisms in oceanic populations
Authors: Jun Ohashi
Izumi Naka
Ryosuke Kimura
Kazumi Natsuhara
Taro Yamauchi
Takuro Furusawa
Minato Nakazawa
Yuji Ataka
Jintana Patarapotikul
Pornlada Nuchnoi
Katsushi Tokunaga
Takafumi Ishida
Tsukasa Inaoka
Yasuhiro Matsumura
Ryutaro Ohtsuka
University of Tokyo
Tokai University
Fukuoka Prefectural University
Hokkaido University
Gunma University
Kwansei Gakuin University
Mahidol University
Saga University
National Institute of Health and Nutrition Tokyo
National Institute for Environmental Studies of Japan
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Dec-2007
Citation: Journal of Human Genetics. Vol.52, No.12 (2007), 1031-1035
Abstract: It has been suggested that Neel's "thrifty genotype" model may account for high body weights in some Oceanic populations, which presumably arose in modern times. In European populations, common variants (rs1421085-C, rs17817449-G, and rs9939609-A) in the fat mass and obesity (FTO associated) were recently found to be associated with body mass index (BMI) or obesity. In this study, we investigated the population frequencies of these variants in six Oceanic populations (Melanesians, Micronesians, and Polynesians) and tested for an association with BMI. Unlike European populations, the Oceanic populations displayed no significant association between the FTO polymorphisms and BMI. These variants were in strong linkage disequilibrium. The population frequencies ranged between 4.2 and 30.3% in the six Oceanic populations, and were similar to those in southeast and east Asian populations. Our study of the FTO polymorphisms has generated no evidence to support the thrifty genotype hypothesis for Oceanic populations. © 2007 The Japan Society of Human Genetics and Springer.
ISSN: 14345161
Appears in Collections:Scopus 2006-2010

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.