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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/24100
Title: Isolates of Zaire ebolavirus from wild apes reveal genetic lineage and recombinants
Authors: Tatiana J. Wittmann
Roman Biek
Alexandre Hassanin
Pierre Rouquet
Patricia Reed
Philippe Yaba
Xavier Pourrut
Leslie A. Real
Jean Paul Gonzalez
Eric M. Leroy
Centre International de Recherches Medicales de Franceville
Emory University
CNRS Centre National de la Recherche Scientifique
Wildlife Conservation Society
Mahidol University
University of Glasgow
Keywords: Biochemistry, Genetics and Molecular Biology;Multidisciplinary
Issue Date: 23-Oct-2007
Citation: Proceedings of the National Academy of Sciences of the United States of America. Vol.104, No.43 (2007), 17123-17127
Abstract: Over the last 30 years, Zaire ebolavirus (ZEBOV), a virus highly pathogenic for humans and wild apes, has emerged repeatedly in Central Africa. Thus far, only a few virus isolates have been characterized genetically, all belonging to a single genetic lineage and originating exclusively from infected human patients. Here, we describe the first ZEBOV sequences isolated from great ape carcasses in the Gabon/Congo region that belong to a previously unrecognized genetic lineage. According to our estimates, this lineage, which we also encountered in the two most recent human outbreaks in the Republic of the Congo in 2003 and 2005, diverged from the previously known viruses around the time of the first documented human outbreak in 1976. These results suggest that virus spillover from the reservoir has occurred more than once, as predicted by the multiple emergence hypothesis. However, the young age of both ZEBOV lineages and the spatial and temporal sequence of outbreaks remain at odds with the idea that the virus simply emerged from a long-established and widespread reservoir population. Based on data from two ZEBOV genes, we also demonstrate, within the family Filoviridae, recombination between the two lineages. According to our estimates, this event took place between 1996 and 2001 and gave rise to a group of recombinant viruses that were responsible for a series of outbreaks in 2001-2003. The potential for recombination adds an additional level of complexity to unraveling and potentially controlling the emergence of ZEBOV in humans and wildlife species. © 2007 by The National Academy of Sciences of the USA.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=36749025693&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/24100
ISSN: 10916490
00278424
Appears in Collections:Scopus 2006-2010

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