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Title: Anhydrocochlioquinone A, a new antitumor compound from Bipolaris oryzae
Authors: Preecha Phuwapraisirisan
Knokwan Sawang
Pongpun Siripong
Santi Tip-pyang
Mahidol University
Chulalongkorn University
National Cancer Institute Thailand
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 23-Jul-2007
Citation: Tetrahedron Letters. Vol.48, No.30 (2007), 5193-5195
Abstract: In the search for antitumor compounds from Bipolaris oryzae, the coexistence of ophiobolins and cochlioquinones is reported for the first time. Of the compounds isolated, anhydrocochlioquinone A (7) was identified as a new antitumor agent. The structure of 7 was fully characterized by spectroscopic data, including COSY, HSQC, HMBC, and NOESY. The cytotoxicity of isolated compounds against HeLa and KB cells is also described. © 2007 Elsevier Ltd. All rights reserved.
ISSN: 00404039
Appears in Collections:Scopus 2006-2010

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