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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/24163
Title: Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors
Authors: Koji Matsuoka
Chiharu Takita
Tetsuo Koyama
Daisei Miyamoto
Sangchai Yingsakmongkon
Kazuya I.P.J. Hidari
Wipawee Jampangern
Takashi Suzuki
Yasuo Suzuki
Ken Hatano
Daiyo Terunuma
Graduate School of Science and Engineering
University of Shizuoka
Japan Science and Technology Agency
Kasetsart University
Mahidol University
Chubu University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 15-Jul-2007
Citation: Bioorganic and Medicinal Chemistry Letters. Vol.17, No.14 (2007), 3826-3830
Abstract: A conventional synthesis of α-thioglycoside of sialic acid as a glycomonomer was accomplished. Radical copolymerization of the glycomonomer with vinyl acetate proceeded smoothly to afford a new class of glycopolymers having thiosialoside residues, in which all protection was removed by a combination of transesterification and saponification to provide a water-soluble thiosialoside cluster. The results of a preliminary study on biological responses against influenza virus neuraminidases using the thiosialoside polymer as a candidate for a neuraminidase inhibitor showed that the glycopolymer has potent inhibitory activity against the neuraminidases. © 2007 Elsevier Ltd. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34250351179&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/24163
ISSN: 0960894X
Appears in Collections:Scopus 2006-2010

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