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|Title:||Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors|
Kazuya I.P.J. Hidari
Graduate School of Science and Engineering
University of Shizuoka
Japan Science and Technology Agency
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Bioorganic and Medicinal Chemistry Letters. Vol.17, No.14 (2007), 3826-3830|
|Abstract:||A conventional synthesis of α-thioglycoside of sialic acid as a glycomonomer was accomplished. Radical copolymerization of the glycomonomer with vinyl acetate proceeded smoothly to afford a new class of glycopolymers having thiosialoside residues, in which all protection was removed by a combination of transesterification and saponification to provide a water-soluble thiosialoside cluster. The results of a preliminary study on biological responses against influenza virus neuraminidases using the thiosialoside polymer as a candidate for a neuraminidase inhibitor showed that the glycopolymer has potent inhibitory activity against the neuraminidases. © 2007 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Scopus 2006-2010|
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