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|Title:||Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-κB-inhibiting activity|
Walter J. Wurzer
Westfalische Wilhelms-Universitat Munster
Justus Liebig University Giessen
Robert Koch Institut
|Keywords:||Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology|
|Citation:||Cellular Microbiology. Vol.9, No.7 (2007), 1683-1694|
|Abstract:||Influenza is still one of the major plagues worldwide. The statistical likeliness of a new pandemic outbreak highlights the urgent need for new and amply available antiviral drugs. We and others have shown that influenza virus misuses the cellular IKK/NF-κB signalling pathway for efficient replication suggesting that this module may be a suitable target for antiviral intervention. Here we examined acetylsalicylic acid (ASA), also known as aspirin, a widely used drug with a well-known capacity to inhibit NF-κB. We show that the drug efficiently blocks influenza virus replication in vitro and in vivo in a mechanism involving impaired expression of proapoptotic factors, subsequent inhibition of caspase activation as well as block of caspase-mediated nuclear export of viral ribonucleoproteins. As ASA showed no toxic side-effects or the tendency to induce resistant virus variants, existing salicylate-based aerosolic drugs may be suitable as anti-influenza agents. This is the first demonstration that specific targeting of a cellular factor is a suitable approach for anti-influenza virus intervention. © 2007 The Authors; Journal compilation © 2007 Blackwell Publishing Ltd.|
|Appears in Collections:||Scopus 2006-2010|
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