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Title: The genotypes of GYPA and GYPB carrying the MNSs antigens are not associated with cerebral malaria
Authors: Izumi Naka
Jun Ohashi
Jintana Patarapotikul
Hathairad Hananantachai
Polrat Wilairatana
Sornchai Looareesuwan
Katsushi Tokunaga
University of Tokyo
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-May-2007
Citation: Journal of Human Genetics. Vol.52, No.5 (2007), 476-479
Abstract: Plasmodium falciparum invades erythrocytes via several routes using different red blood cell receptors that include glycophorin A (GYPA) and glycophorin B (GYPB). GYPA has two codominant alleles, i.e., M and N, that correspond to the M and N antigens, which differ by two amino acids (S1L, G5E); the codominant alleles of GYPB, i.e., S and s, correspond to the S and s antigens, which differ by a single amino acid (T29M). If these antigens influence the efficiency of erythrocyte invasion by malaria parasites, the MNSs phenotype may be associated with the severity of malaria. To examine this, the GYPA and GYPB genotypes carrying the MNSs antigens were analyzed in 109 and 203 Thai patients with cerebral malaria and mild malaria, respectively. Neither the genotype nor allele frequencies at each locus were statistically different between the cerebral and mild malaria patients. Thus, we conclude that the MNSs antigens do not reveal the difference in susceptibility to cerebral malaria. © 2007 The Japan Society of Human Genetics and Springer.
ISSN: 14345161
Appears in Collections:Scopus 2006-2010

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