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Title: Significant association between TNF-α (TNF) promoter allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand
Authors: H. Hananantachai
J. Patarapotikul
J. Ohashi
I. Naka
S. Krudsood
S. Looareesuwan
K. Tokunaga
Mahidol University
University of Tokyo
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 1-Mar-2007
Citation: Tissue Antigens. Vol.69, No.3 (2007), 277-280
Abstract: We examined a possible association of three single nucleotide polymorphisms (SNPs) of the tumor necrosis factor alpha (TNF) promoter -1031T>C (rs1799964), -863C>A (rs1800630), and -857C>T (rs1799724) with severe malaria in 466 adult patients having Plasmodium falciparum malaria in northwest Thailand. Four TNF promoter alleles comprising these three SNPs were detected in the studied population. The frequency of the TNF U04 allele designated -1031C, -863C, and -857C was found to be significantly greater in patients with cerebral malaria than in patients with mild malaria (12.6%, cerebral malaria vs 5.6%, mild malaria; odds ratio = 2.5; P = 0.002). The association of U04 with susceptibility to cerebral malaria was not caused by linkage disequilibrium with any specific HLA-B and -DRB1 alleles. © 2007 Blackwell Munksgaard.
ISSN: 13990039
Appears in Collections:Scopus 2006-2010

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