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Title: Isolation and characterization of cancer chemopreventive compounds from Barringtonia maunwongyathiae
Authors: Aranya Jutiviboonsuk
Hong Jie Zhang
Tamara P. Kondratyuk
Angkana Herunsalee
Wongsatit Chaukul
John M. Pezzuto
Harry H.S. Fong
Nuntavan Bunyapraphatsara
Mahidol University
University of Illinois at Chicago
Purdue University
Thailand Ministry of Public Health
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Mar-2007
Citation: Pharmaceutical Biology. Vol.45, No.3 (2007), 185-194
Abstract: A new plant species, Barringtonia maunwongyathiae W. Chuakul (Lecythidaceae), was recently discovered in Khuan Thon Forest, Ao Luek District, Krabi Province, Thailand. Chemical investigation of the leaves of this plant led to the isolation of 10 triterpenes, 3 steroids, and a vitamin E derivative. The structures of these compounds were identified as taraxerol (1), 3-(E)-coumaroyltaraxerol (2), 3-(Z)-coumaroyltaraxerol (3), 3-(E)-coumaroyl β-amyrin (4), 3-(Z)-coumaroyl β-amyrin (5), 3-(E)-coumaroyl α-amyrin (6), 3-(Z)-coumaroyl α-amyrin (7), 3-(E)-coumaroyllupeol (8), 3-(Z)-coumaroyllupeol (9), 3,19,24-trihydroxyurs-12-ene-28-oic acid (10), stigma-4,22-dien-3-one (11), β-stigmasterol (12), 3-O-β-D- glucopyranosyl-stigmasta-5,22-diene (13), and α-tocopherylquinone (14). All compounds were evaluated for their cancer chemopreventive potential based on inhibition of TPA-induced ornithine decarboxylase expression, COX-1 and COX-2 activities, and phorbol ester-induced NF-κB luciferase expression, as well as activation of antioxidant response element-mediated luciferase expression. Compounds 1, 2, and 14 demonstrated greatest promise, while 12 and 13 showed moderate activity. © 2007 Informa Healthcare.
ISSN: 17445116
Appears in Collections:Scopus 2006-2010

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