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dc.contributor.authorAranya Jutiviboonsuken_US
dc.contributor.authorHong Jie Zhangen_US
dc.contributor.authorTamara P. Kondratyuken_US
dc.contributor.authorAngkana Herunsaleeen_US
dc.contributor.authorWongsatit Chaukulen_US
dc.contributor.authorJohn M. Pezzutoen_US
dc.contributor.authorHarry H.S. Fongen_US
dc.contributor.authorNuntavan Bunyapraphatsaraen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Illinois at Chicagoen_US
dc.contributor.otherPurdue Universityen_US
dc.contributor.otherThailand Ministry of Public Healthen_US
dc.identifier.citationPharmaceutical Biology. Vol.45, No.3 (2007), 185-194en_US
dc.description.abstractA new plant species, Barringtonia maunwongyathiae W. Chuakul (Lecythidaceae), was recently discovered in Khuan Thon Forest, Ao Luek District, Krabi Province, Thailand. Chemical investigation of the leaves of this plant led to the isolation of 10 triterpenes, 3 steroids, and a vitamin E derivative. The structures of these compounds were identified as taraxerol (1), 3-(E)-coumaroyltaraxerol (2), 3-(Z)-coumaroyltaraxerol (3), 3-(E)-coumaroyl β-amyrin (4), 3-(Z)-coumaroyl β-amyrin (5), 3-(E)-coumaroyl α-amyrin (6), 3-(Z)-coumaroyl α-amyrin (7), 3-(E)-coumaroyllupeol (8), 3-(Z)-coumaroyllupeol (9), 3,19,24-trihydroxyurs-12-ene-28-oic acid (10), stigma-4,22-dien-3-one (11), β-stigmasterol (12), 3-O-β-D- glucopyranosyl-stigmasta-5,22-diene (13), and α-tocopherylquinone (14). All compounds were evaluated for their cancer chemopreventive potential based on inhibition of TPA-induced ornithine decarboxylase expression, COX-1 and COX-2 activities, and phorbol ester-induced NF-κB luciferase expression, as well as activation of antioxidant response element-mediated luciferase expression. Compounds 1, 2, and 14 demonstrated greatest promise, while 12 and 13 showed moderate activity. © 2007 Informa Healthcare.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleIsolation and characterization of cancer chemopreventive compounds from Barringtonia maunwongyathiaeen_US
Appears in Collections:Scopus 2006-2010

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