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|Title:||Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors|
|Authors:||Jun Ichi Sakamoto|
Kazuya I.P.J. Hidari
University of Shizuoka
Japan Science and Technology Agency
RIKEN (The Institute of Physical and Chemical Research)
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Bioorganic and Medicinal Chemistry Letters. Vol.17, No.3 (2007), 717-721|
|Abstract:||An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with α-thioglycoside of sialic acid was accomplished. The results of a preliminary study on biological responses against influenza virus sialidases using thiosialoside clusters showed that some of the glycodendrimers have inhibitory potencies against the sialidases. © 2006 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Scopus 2006-2010|
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