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Title: Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors
Authors: Jun Ichi Sakamoto
Tetsuo Koyama
Daisei Miyamoto
Sangchai Yingsakmongkon
Kazuya I.P.J. Hidari
Wipawee Jampangern
Takashi Suzuki
Yasuo Suzuki
Yasuaki Esumi
Ken Hatano
Daiyo Terunuma
Koji Matsuoka
Saitama University
University of Shizuoka
Japan Science and Technology Agency
Kasetsart University
Mahidol University
Chubu University
RIKEN (The Institute of Physical and Chemical Research)
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Feb-2007
Citation: Bioorganic and Medicinal Chemistry Letters. Vol.17, No.3 (2007), 717-721
Abstract: An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with α-thioglycoside of sialic acid was accomplished. The results of a preliminary study on biological responses against influenza virus sialidases using thiosialoside clusters showed that some of the glycodendrimers have inhibitory potencies against the sialidases. © 2006 Elsevier Ltd. All rights reserved.
ISSN: 0960894X
Appears in Collections:Scopus 2006-2010

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