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Title: Clinical proteomics: A need to define the field and to begin to set adequate standards
Authors: Harald Mischak
Rolf Apweiler
Rosamonde E. Banks
Mark Conaway
Joshua Coon
Anna Dominiczak
Jochen H.H. Ehrich
Danilo Fliser
Mark Girolami
Henning Hermjakob
Denis Hochstrasser
Joachim Jankowski
Bruce A. Julian
Walter Kolch
Ziad A. Massy
Christian Neusuess
Jan Novak
Karlheinz Peter
Kasper Rossing
Joost Schanstra
O. John Semmes
Dan Theodorescu
Visith Thongboonkerd
Eva M. Weissinger
Jennifer E. Van Eyk
Tadashi Yamamoto
Mosaiques Diagnostics and Therapeutics AG
European Bioinformatics Institute
St James's University Hospital
University of Virginia
University of Wisconsin Madison
University of Glasgow
Medizinische Hochschule Hannover (MHH)
Charité – Universitätsmedizin Berlin
Universite de Geneve
University of Alabama at Birmingham
Beatson Institute for Cancer Research
University of Aalen
Baker Heart and Diabetes Institute
Steno Diabetes Center
Eastern Virginia Medical School
Mahidol University
Johns Hopkins University
Niigata University School of Medicine
CHU Amiens Picardie
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Feb-2007
Citation: Proteomics - Clinical Applications. Vol.1, No.2 (2007), 148-156
Abstract: The aim of this manuscript is to initiate a constructive discussion about the definition of clinical proteomics, study requirements, pitfalls and (potential) use. Furthermore, we hope to stimulate proposals for the optimal use of future opportunities and seek unification of the approaches in clinical proteomic studies. We have outlined our collective views about the basic principles that should be considered in clinical proteomic studies, including sample selection, choice of technology and appropriate quality control, and the need for collaborative interdisciplinary efforts involving clinicians and scientists. Furthermore, we propose guidelines for the critical aspects that should be included in published reports. Our hope is that, as a result of stimulating discussion, a consensus will be reached amongst the scientific community leading to guidelines for the studies, similar to those already published for mass spectrometric sequencing data. We contend that clinical proteomics is not just a collection of studies dealing with analysis of clinical samples. Rather, the essence of clinical proteomics should be to address clinically relevant questions and to improve the state-of-the-art, both in diagnosis and in therapy of diseases. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISSN: 18628346
Appears in Collections:Scopus 2006-2010

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