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Title: Serotype distribution and antimicrobial susceptibility of S. pneumoniae causing invasive disease in Thai children younger than 5 years old, 2000-2005
Authors: Wanatpreeya Phongsamart
Somporn Srifeungfung
Surang Dejsirilert
Tanittha Chatsuwan
Pongpun Nunthapisud
Vipa Treerauthaweeraphong
Pimpha Rungnobhakhun
Kulkanya Chokephaibulkit
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine;Veterinary
Issue Date: 26-Jan-2007
Citation: Vaccine. Vol.25, No.7 (2007), 1275-1280
Abstract: In order to predict the potential benefit of pneumococcal conjugate vaccines (PCV), we evaluated the serotype coverage of the 7-, 9-, 11- and 13-valent PCV over the isolates causing invasive pneumococcal disease (IPD) in Thai children. One hundred and fifteen Streptococcus pneumoniae isolates from sterile sites in children younger than 5 years old between 2000 and 2005 were serotyped. The coverages of 7-, 9-, 11-, and 13-valent PCV were 69%, 73.8%, 73.8% and 85.7% in children younger than 2 years, and 73.9%, 77.4%, 77.4% and 87.8% in children younger than 5 years of age, respectively. 69.6% and 22.6% of the isolates were non-susceptible to penicillin and cefotaxime. 7-valent PCV covered 89% and 100% of penicillin and cefotaxime non-susceptible isolates. © 2006 Elsevier Ltd. All rights reserved.
ISSN: 0264410X
Appears in Collections:Scopus 2006-2010

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