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dc.contributor.authorTanett Pakeetooten_US
dc.contributor.authorPhaibul Punyariten_US
dc.contributor.authorSongsak Petmitren_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherPhramongkutklao College of Medicineen_US
dc.identifier.citationAsian Pacific Journal of Cancer Prevention. Vol.8, No.1 (2007), 83-86en_US
dc.description.abstractBreast cancer is the most common cancer among women worldwide. Genetic alterations prevalent in breast cancer are still being elucidated. In this report, changes in 30 breast cancer tissues, in compariosn with normal tissues from Thai patients, were analyzed by arbitrarily primed polymerase chain reaction (AP-PCR). Genetic instability was detected by DNA fingerprinting obtained with 13 of 60 random primers. Of these, at least one amplification band, the incidence ranging from 27 to 80%, was observed in DNA amplified with 8 primers, whereas a band loss was exhibited with from 6 primers, the incidences ranging from 23 to 40%. Likewise, an amplification band amplified from primer D15 was observed in 80% of this patient group and a band loss produced from primer B12 presented in 40% of all cases. These results showed that AP-PCR is effective for the detection of genetic alterations in breast cancer tissues.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleIdentification of genetic alterations in Thai breast cancer patients by arbitrarily primed polymerase chain reactionen_US
Appears in Collections:Scopus 2006-2010

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