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Title: Growth hormone treatment in adolescent males with idiopathic short stature: Changes in body composition, protein, fat, and glucose metabolism
Authors: Tamara S. Hannon
Kapriel Danadian
Chittiwat Suprasongsin
Silva A. Arslanian
University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh
Oneida Pediatric Group
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-2007
Citation: Journal of Clinical Endocrinology and Metabolism. Vol.92, No.8 (2007), 3033-3039
Abstract: Context: Cross-sectional observations show an inverse relationship between pubertal increase in GH and insulin sensitivity, suggesting that pubertal insulin resistance may be mediated by GH. Objective: Our objective was to assess longitudinally the effects of short-term GH supplementation in adolescent males with non-GH-deficient idiopathic short stature (ISS) on body composition, substrate metabolism, and insulin sensitivity. Children with ISS were studied to simulate the pubertal increase in GH secretion. Participants and Setting: Eight males with ISS (10.8-16.5 yr) were recruited from pediatric endocrinology clinics at an academic medical center. Study Design: Participants were evaluated in the General Clinical Research Center before and after 4 months of GH supplementation (0.3 mg/kg·wk). Body composition was assessed with dual-energy x-ray absorptiometry. Whole-body glucose, protein, and fat turnover were measured using stable isotopes. In vivo insulin action was assessed during a 3-h hyperinsulinemic (40 mU/m2·min) euglycemic clamp. Results: GH supplementation led to 1) increase in hepatic glucose production and fasting insulin levels, 2) increase in lean body mass and decrease in fat mass, and 3) improvement in cardiovascular lipid risk profile. Plasma IGF-I levels correlated positively with insulin levels. Conclusions: Four months of GH supplementation in adolescent males with ISS is associated with significant body composition changes and hepatic insulin resistance. Copyright © 2007 by The Endocrine Society.
ISSN: 0021972X
Appears in Collections:Scopus 2006-2010

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