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|Title:||Novel 2-chloro-8-arylthiomethyldipyridodiazepinone derivatives with activity against HIV-1 reverse transcriptase|
Chulabhorn Research Institute
Ubon Rajathanee University
|Citation:||Molecules. Vol.12, No.2 (2007), 218-230|
|Abstract:||Based on the molecular modeling analysis against Y181C HIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactam nitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficient route. Some of them were evaluated for their antiviral activity against HIV-1 RT subtype E and were found to exhibit virustatic activity comparable to some clinically used therapeutic agents. © 2007 by MDPI.|
|Appears in Collections:||Scopus 2006-2010|
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