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Title: Novel 2-chloro-8-arylthiomethyldipyridodiazepinone derivatives with activity against HIV-1 reverse transcriptase
Authors: Nisachon Khunnawutmanotham
Nitirat Chimnoi
Patchareenart Saparpakorn
Pornpan Pungpo
Suda Louisirirotchanakul
Supa Hannongbua
Supanna Techasakul
Chulabhorn Research Institute
Kasetsart University
Ubon Rajathanee University
Mahidol University
Keywords: Chemistry
Issue Date: 1-Feb-2007
Citation: Molecules. Vol.12, No.2 (2007), 218-230
Abstract: Based on the molecular modeling analysis against Y181C HIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactam nitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficient route. Some of them were evaluated for their antiviral activity against HIV-1 RT subtype E and were found to exhibit virustatic activity comparable to some clinically used therapeutic agents. © 2007 by MDPI.
ISSN: 14203049
Appears in Collections:Scopus 2006-2010

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