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Title: Preparation of novel core-shell nanoparticles as non-viral gene delivery vectors: Surface charge, particle size, and morphology
Authors: Nuttaporn Pimpha
Uracha Ruktanonchai
Suvimol Surassmo
Praneet Opanasopit
Panya Sunintaboon
Thailand National Science and Technology Development Agency
Silpakorn University
Mahidol University
Keywords: Computer Science;Engineering
Issue Date: 28-Aug-2007
Citation: Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. (2007), 1007-1011
Abstract: The well-defined core-shell amphiphilic nanoparticles consisting of the poly(methyl methacrylate) (PMMA) cores surrounded by the modified chitosan shells were prepared via a surfactant-free emulsion graft-copolymerization of methyl methacrylate from an aqueous modified chitosan solution induced by a small amount of tert-butyl hydroperoxide. The PMMA-chitosan core-shell particles have an average particle diameter of approximately 200 nm and display highly positive surface charges (+70 mV). Transmission electron microscopic (TEM) images clearly reveal a well-defined core-shell morphology of the nanoparticles where the PMMA cores are coated with chitosan shells. The core-shell nanoparticles were investigated as novel carriers for gene delivery. The nanoparticle/plasmid DNA complexes were characterized with respect to their binding affinity, particle size, and zeta-potential. © 2007 IEEE.
Appears in Collections:Scopus 2006-2010

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