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|Title:||Preparation of novel core-shell nanoparticles as non-viral gene delivery vectors: Surface charge, particle size, and morphology|
Thailand National Science and Technology Development Agency
|Citation:||Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. (2007), 1007-1011|
|Abstract:||The well-defined core-shell amphiphilic nanoparticles consisting of the poly(methyl methacrylate) (PMMA) cores surrounded by the modified chitosan shells were prepared via a surfactant-free emulsion graft-copolymerization of methyl methacrylate from an aqueous modified chitosan solution induced by a small amount of tert-butyl hydroperoxide. The PMMA-chitosan core-shell particles have an average particle diameter of approximately 200 nm and display highly positive surface charges (+70 mV). Transmission electron microscopic (TEM) images clearly reveal a well-defined core-shell morphology of the nanoparticles where the PMMA cores are coated with chitosan shells. The core-shell nanoparticles were investigated as novel carriers for gene delivery. The nanoparticle/plasmid DNA complexes were characterized with respect to their binding affinity, particle size, and zeta-potential. © 2007 IEEE.|
|Appears in Collections:||Scopus 2006-2010|
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