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Title: Incidence and risk factors of nevirapine-associated skin rashes among HIV-infected patients with CD4 cell counts <250 cells/μL
Authors: Weerawat Manosuthi
Somnuek Sungkanuparph
Somsit Tansuphaswadikul
Yaowarat Inthong
Wisit Prasithsirikul
Suthat Chottanapund
Wiroj Mankatitham
Sukanya Chimsuntorn
Chayanan Sittibusaya
Visal Moolasart
Nopphanath Chumpathat
Patamavadee Termvises
Achara Chaovavanich
Thailand Ministry of Public Health
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Nov-2007
Citation: International Journal of STD and AIDS. Vol.18, No.11 (2007), 782-786
Abstract: The objective of the study was to determine cumulative incidence and risk factors of nevirapine (NVP)-associated rashes that lead to NVP discontinuation among HIV-infected patients with CD4 <250 cells/μL. A retrospective cohort study was conducted among antiretroviral-naïve HIV-infected patients who had baseline CD4 <250 cells/μL and were initiated NVP-based antiretroviral therapy (ART) between January 2003 and October 2005. There were 910 patients with a mean age of 35.4 years and 43% were women. Median CD4 cell count was 27 cells/μL and median HIV RNA was 5.5 log copies/mL. Cumulative incidences of rashes at 0.5, 1, 2, 3 and 6 months after ART were 3.7%, 6.2%, 8.1%, 8.5% and 8.5%, respectively. By Kaplan-Meier analysis, the higher baseline CD4 cell counts had a higher probability of NVP-associated rashes (log-rank test, P = 0.041). By Cox regression analysis, higher baseline CD4 cell count was associated with a higher incidence of rashes (hazard ratio = 1.244, 95% confidence interval = 1.045-1.482, for every 50 cells/μL increment of baseline CD4 stratum). In conclusion, NVP-associated skin rashes that lead to NVP discontinuation are common among HIV-infected patients with baseline CD4 <250 cells/μL. Despite the low baseline in this population, the higher number of baseline CD4 cells is continuously associated with a higher risk for skin rashes.
ISSN: 09564624
Appears in Collections:Scopus 2006-2010

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