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Title: High susceptibility of human dendritic cells to avian influenza H5N1 virus infection and protection by IFN-α and TLR ligands
Authors: Arunee Thitithanyanont
Anneke Engering
Peeraya Ekchariyawat
Suwimon Wiboon-ut
Amporn Limsalakpetch
Kosol Yongvanitchit
Utaiwan Kum-Arb
Watcharoot Kanchongkittiphon
Pongsak Utaisincharoen
Stitaya Sirisinha
Pilaipan Puthavathana
Mark M. Fukuda
Sathit Pichyangkul
Mahidol University
Armed Forces Research Institute of Medical Sciences, Thailand
Keywords: Immunology and Microbiology
Issue Date: 15-Oct-2007
Citation: Journal of Immunology. Vol.179, No.8 (2007), 5220-5227
Abstract: There is worldwide concern that the avian influenza H5N1 virus, with a mortality rate of >50%, might cause the next influenza pandemic. Unlike most other influenza infections, H5N1 infection causes a systemic disease. The underlying mechanisms for this effect are still unclear. In this study, we investigate the interplay between avian influenza H5N1 and human dendritic cells (DC). We showed that H5N1 virus can infect and replicate in monocyte-derived and blood myeloid DC, leading to cell death. These results suggest that H5N1 escapes viral-specific immunity, and could disseminate via DC. In contrast, blood pDC were resistant to infection and produced high amounts of IFN-α. Addition of this cytokine to monocyte-derived DC or pretreatment with TLR ligands protected against infection and the cytopathic effects of H5N1 virus.
ISSN: 15506606
Appears in Collections:Scopus 2006-2010

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