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Title: Effects of malaria heme products on red blood cell deformability
Authors: Forradee Nuchsongsin
Kesinee Chotivanich
Prakaykaew Charunwatthana
Omodeo Salè Fausta
Donatella Taramelli
Nicholas P. Day
Nicholas J. White
Arjen M. Dondorp
Mahidol University
Universita degli Studi di Milano
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Oct-2007
Citation: American Journal of Tropical Medicine and Hygiene. Vol.77, No.4 (2007), 617-622
Abstract: In falciparum malaria, the deformability of the entire erythrocyte population is reduced in proportion to disease severity, and this compromises microcirculatory blood flow through vessels partially obstructed by cytoadherent parasitized erythrocytes. The cause of rigidity of uninfected erythrocytes in not known but could be mediated by malaria heme products. In this study, we show that red blood cell deformability (RBC-D), measured by laser-assisted optical rotational cell analyzer, decreased in a dose-dependent manner after incubation with hemin and hydrogen peroxide but not with hemoglobin or β-hematin. Hemin also reduced mean red cell volume. Albumin decreased and N-acetylcysteine (NAC) both prevented and reversed rigidity induced by hemin. Hemin-induced oxidative damage of the membrane seems to be a more important contributor to pathology than cell shrinkage because the antioxidant NAC restored RBC-D but not red blood cell volume. The findings suggest novel approaches to the treatment of potentially lethal malaria. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2006-2010

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