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Title: Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development
Authors: Ernest Beutler
Stephan Duparc
Ogobara Doumbo
Kanjaksha Ghosh
Marcus Vinicius Guimaraes De Lacerda
Didier Lapierre
Sornchai Looareesuwan
Zulfiqarali Premji
Tom Vulliamy
Christopher Whitty
Scripps Research Institute
International Center Cointrin
University of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatology
Institute of Immunohaematology Mumbai
Fundacao de Medicina Tropical do Amazonas
GlaxoSmithKline plc.
Mahidol University
University of Dar Es Salaam
Imperial College London
London School of Hygiene & Tropical Medicine
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Oct-2007
Citation: American Journal of Tropical Medicine and Hygiene. Vol.77, No.4 (2007), 779-789
Abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is relatively common in populations exposed to malaria. This deficiency appears to provide some protection from this infection, but it can also cause hemolysis after administration of some antimalarial drugs, especially primaquine. The risk of drug-induced G6PD deficiency-related hemolysis depends on a number of factors including the G6PD variant, the drug and drug dosage schedule, patient status, and disease factors. Although a great deal is known about the molecular biology of G6PD, determining the potential for drug-induced hemolysis in the clinical setting is still challenging. This report discusses the potential strategies for assessing drug-induced G6PD deficiency-related hemolytic risk preclinically and in early clinical trials. Additionally, the issues important for conducting larger clinical trials in populations in which G6PD deficiency is prevalent are examined, with a particular focus on antimalarial drug development. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2006-2010

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