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Title: IFN-γ-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations
Authors: Peter A.B. Wark
Fabio Bucchieri
Sebastian L. Johnston
Peter G. Gibson
Lynnsey Hamilton
Joanna Mimica
Giovanni Zummo
Stephen T. Holgate
John Attia
Ammarin Thakkinstian
Donna E. Davies
University of Southampton
National Heart and Lung Institute
Universita degli Studi di Palermo
John Hunter Hospital
University of Newcastle, Australia
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Sep-2007
Citation: Journal of Allergy and Clinical Immunology. Vol.120, No.3 (2007), 586-593
Abstract: Background: Rhinovirus-induced acute asthma is the most frequent trigger for asthma exacerbations. Objective: We assessed which inflammatory mediators were released from bronchial epithelial cells (BECs) after infection with rhinovirus and then determined whether they were also present in subjects with acute virus-induced asthma, with the aim to identify a biomarker or biomarkers for acute virus-induced asthma. Methods: BECs were obtained from bronchial brushings of steroid-naive asthmatic subjects and healthy nonatopic control subjects. Cells were infected with rhinovirus 16. Inflammatory mediators were measured by means of flow cytometry with a cytometric bead array. Subjects with acute asthma and virus infection were recruited; they were characterized clinically by using lung function tests and had blood taken to measure the inflammatory mediators identified as important by the BEC experiments. Results: IFN-γ-induced protein 10 (IP-10) and RANTES were released in the greatest quantities, followed by IL-6, IL-8, and TNF-α. Dexamethasone treatment of BECs only partially suppressed IP-10 and TNF-α but was more effective at suppressing RANTES, IL-6, and IL-8. In acute clinical asthma serum IP-10 levels were increased to a greater extent in those with acute virus-induced asthma (median of 604 pg/mL compared with 167 pg/mL in those with non-virus-induced acute asthma, P < .01). Increased serum IP-10 levels were predictive of virus-induced asthma (odds ratio, 44.3 [95% CI, 3.9-100.3]). Increased serum IP-10 levels were strongly associated with more severe airflow obstruction (r = -0.8; P < .01). Conclusions: IP-10 release is specific to acute virus-induced asthma. Clinical implications: Measurement of serum IP-10 could be used to predict a viral trigger to acute asthma. © 2007 American Academy of Allergy, Asthma & Immunology.
ISSN: 00916749
Appears in Collections:Scopus 2006-2010

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