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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/24523
Title: Ferritin levels during structured treatment interruption of highly active antiretroviral therapy
Authors: José Boom
E. Kösters
C. Duncombe
S. Kerr
B. Hirschel
K. Ruxrungtham
Q. De Mast
P. Kosalaraksa
S. Ulbolyam
T. Jupimai
J. Ananworanich
Praphan Phanuphak
David A. Copper
Apicha Mahanontharit
Wisit Prasithsirikul
Ploenchan Chetchotisakda
Sasisopin Kiertiburanakul
Warangkana Munsakul
Phitsanu Raksakulkarn
Somboon Tansuphasawadikul
Sukontha Saenawat
Saijai Wicharuk
Siriporn Nonenoy
Natnipa Wannachai
Theshinee Chuenyam
Vrije Universiteit Amsterdam
Radboud University Nijmegen Medical Centre
The HIV Netherlands Australia Thailand Research Collaboration
Kirby Institute
Hopitaux universitaires de Geneve
Chulalongkorn University
Khon Kaen University
Southeast Asia Research Collaboration with Hawaii (SEARCH)
Bamrasnaradura Infectious Disease Institute
Mahidol University
Vajira Hospital
Sanpatong Hospital
Buddhachinnaraj Hospital
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Sep-2007
Citation: HIV Medicine. Vol.8, No.6 (2007), 388-395
Abstract: Objective: The aim of the study was to investigate the influence of highly active antiretroviral therapy (HAART) on iron status and, conversely, the influence of iron status on the response to HAART. Methods: Ferritin levels were retrospectively determined in stored plasma from 138 HAART-naïve, moderately immunosuppressed HIV-infected Thai patients participating in a structured treatment interruption trial. Ferritin levels were determined at three predefined time-points: (1) HAART initiation; (2) HAART discontinuation; and (3) HAART resumption. Results: At baseline, 31% and 16% of the HIV-infected patients included in the study had high (>200 ng/mL) and low (<30 ng/mL) ferritin levels, respectively. Ninety-five per cent of patients with low ferritin levels were female. Ferritin decreased significantly during the interruption phase of HAART (-8.8ng/mL; P=0.0005) but remained elevated in 62% of the patients with high baseline levels. A low baseline ferritin level was associated with a shorter time (P= 0.041) to reach the CD4 cell target for HAART interruption (350cells/μL), compared with a normal or high baseline ferritin level. Moreover, in a multivariate model, the relative risk (RR) of arriving at this CD4 cell target was significantly higher [RR 1.81; 95% confidence interval (CI) 1.05-3.14] in patients with low baseline ferritin. It is unlikely that inflammation affected ferritin in our patients, as mean levels of C-reactive protein were not elevated in patients with either high or low ferritin levels. Conclusions: Both high and low ferritin levels were highly prevalent in moderately immunosuppressed HIV-positive Thai patients. Structured treatment interruption of HAART resulted in a significant decrease in overall ferritin levels. Furthermore, subjects with low baseline ferritin levels had a faster and greater CD4 response to HAART, suggesting a potential beneficial effect of iron deficiency on immunological recovery after initiation of HAART. © 2007 British HIV Association.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34547483341&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/24523
ISSN: 14681293
14642662
Appears in Collections:Scopus 2006-2010

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