Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/24549
Title: High-throughput mRNA profiling characterizes the expression of inflammatory molecules in sepsis caused by Burkholderia pseudomallei
Authors: W. Joost Wiersinga
Mark C. Dessing
Piet A. Kager
Allen C. Cheng
Direk Limmathurotsakul
Nicholas P. Day
Arjen M. Dondorp
Tom Van Der Poll
Sharon J. Peacock
Academic Medical Centre, University of Amsterdam
Menzies School of Health Research
Mahidol University
University of Oxford
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jun-2007
Citation: Infection and Immunity. Vol.75, No.6 (2007), 3074-3079
Abstract: Sepsis is characterized by an uncontrolled inflammatory response to invading microorganisms. We describe the inflammatory mRNA profiles in whole-blood leukocytes, monocytes, and granulocytes using a multigene system for 35 inflammatory markers that included pro- and anti-inflammatory cytokines, chemokines, and signal transduction molecules in a case-control study with 34 patients with sepsis caused by the gram-negative bacterium Burkholderia pseudomalki (the pathogen causing melioidosis) and 32 healthy volunteers. Relative to healthy controls, patients with sepsis showed increased transcription of a whole array of inflammatory genes in peripheral blood leukocytes, granulocytes, and monocytes. Specific monocyte and granulocyte mRNA profiles were identified. Strong correlations were found between inflammatory mRNA expression levels in monocytes and clinical outcome. These data underline the notion that circulating leukocytes are an important source for inflammatory mediators in patients with gram-negative sepsis. Gene profiling such as was done here provides an excellent tool to obtain insight into the extent of inflammation activation in patients with severe infection. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34249894437&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/24549
ISSN: 00199567
Appears in Collections:Scopus 2006-2010

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.