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dc.contributor.authorL. E. Pereiraen_US
dc.contributor.authorF. Villingeren_US
dc.contributor.authorN. Onlamoonen_US
dc.contributor.authorP. Bryanen_US
dc.contributor.authorA. Cardonaen_US
dc.contributor.authorK. Pattanapanysaten_US
dc.contributor.authorK. Morien_US
dc.contributor.authorS. Hagenen_US
dc.contributor.authorL. Pickeren_US
dc.contributor.authorA. A. Ansarien_US
dc.contributor.otherEmory University School of Medicineen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThailand Research Funden_US
dc.contributor.otherNational Institute of Infectious Diseasesen_US
dc.contributor.otherOregon National Primate Research Centeren_US
dc.identifier.citationJournal of Virology. Vol.81, No.9 (2007), 4445-4456en_US
dc.description.abstractDifferences in clinical outcome of simian immunodeficiency virus (SIV) infection in disease-resistant African sooty mangabeys (SM) and disease-susceptible Asian rhesus macaques (RM) prompted us to examine the role of regulatory T cells (Tregs) in these two animal models. Results from a cross-sectional study revealed maintenance of the frequency and absolute number of peripheral Tregs in chronically SIV-infected SM while a significant loss occurred in chronically SIV-infected RM compared to uninfected animals. A longitudinal study of experimentally SIV-infected animals revealed a transient increase in the frequency of Tregs from baseline values following acute infection in RM, but no change in the frequency of Tregs occurred in SM during this period. Further examination revealed a strong correlation between plasma viral load (VL) and the level of Tregs in SIV-infected RM but not SM. A correlation was also noted in SIV-infected RM that control VL spontaneously or in response to antiretroviral chemotherapy. In addition, immunofluorescent cell count assays showed that while Treg-depleted peripheral blood mononuclear cells from RM led to a significant enhancement of CD4+ and CD8+ T-cell responses to select pools of SIV peptides, there was no detectable T-cell response to the same pool of SIV peptides in Treg-depleted cells from SIV-infected SM. Our data collectively suggest that while Tregs do appear to play a role in the control of viremia and the magnitude of the SIV-specific immune response in RM, their role in disease resistance in SM remains unclear. Copyright © 2007, American Society for Microbiology. All Rights Reserved.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleSimian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeysen_US
Appears in Collections:Scopus 2006-2010

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