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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/24564
Title: Suppression by Curcuma comosa Roxb. of pro-inflammatory cytokine secretion in phorbol-12-myristate-13-acetate stimulated human mononuclear cells
Authors: Amorntus Sodsai
Pawinee Piyachaturawat
Samaisukh Sophasan
Apichart Suksamrarn
Molvibha Vongsakul
Mahidol University
Ramkhamhaeng University
Keywords: Immunology and Microbiology;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Apr-2007
Citation: International Immunopharmacology. Vol.7, No.4 (2007), 524-531
Abstract: Curcuma comosa Roxb. is a medicinal plant that has traditionally been used in Thailand for treatment of inflammation in postpartum uterine bleeding. The purpose of this study was to evaluate its anti-inflammatory effects using peripheral blood mononuclear cells (PBMC) and human pro-monocytic cell line (U937). Pretreatment with hexane or ethanol extract or two diarylhepatanoids (5-hydroxy-7-(4-hydroxyphenyl)-1-phenyl-(1E)-1-heptene and 7-(3,4-dihydroxyphenyl)-5-hydroxy-1-phenyl-(1E)-1-heptene) of C. comosa significantly decreased the release of pro-inflammatory cytokines, tumor necrosis factor α (TNF-α) and interleukin-1β, from phorbol-12-myristate-13-acetate (PMA)-stimulated PBMC and U937 cells. In PMA-stimulated U937 cells, the two C. comosa diarylhepatanoids reduced the expression of TNF-α and suppressed expression of IκB kinase and activation of nuclear factor kappa B. These results indicated that C. comosa and its diarylheptanoids have anti-inflammatory properties which could be exploited for clinical use. © 2007 Elsevier B.V. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33847071264&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/24564
ISSN: 15675769
Appears in Collections:Scopus 2006-2010

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